George Clooney, John Malkovich, Tilda Swinton, Frances McDormand, Brad Pitt, Richard Jenkins, J.K. Simmons, David Rasche, Olek Krupa, Jeffrey DeMunn, Crystal Bock
A CIA analyst, Osbourne Cox (John Malkovich), quits after being demoted because of his problems with alcohol. He writes a memoir of his life in the Agency. By accident, the manuscript, on a CD, is found by two unscrupulous employees of a fitness center (Brad Pitt and Frances McDormand). They try to blackmail Osbourne, thinking that they found top secret government materials. George Clooney steps into the story as an investigator.